Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155731 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-5, N-terminally processed
Molecule details ›
Chain: A
Length: 467 amino acids
Theoretical weight: 51.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 467 amino acids
Theoretical weight: 51.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P52294 (Residues: 73-538; Coverage: 87%)
Sequence domains:
Transcription factor SOX-2
Molecule details ›
Chain: B
Length: 90 amino acids
Theoretical weight: 11.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: HMG (high mobility group) box
Length: 90 amino acids
Theoretical weight: 11.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P48431 (Residues: 39-127; Coverage: 28%)
Sequence domains: HMG (high mobility group) box
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup:
C2
Expression system: Escherichia coli
