› 6x3i

X-ray diffraction
2.27Å resolution

NNAS Fc mutant

Released:
DOI: 10.2210/pdb6x3i/pdb
Model geometry
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PDB entry 6x3i coloured by chain, front view.
PDB entry 6x3i coloured by chain, side view.
PDB entry 6x3i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Engineered Fc-glycosylation switch to eliminate antibody effector function.
Zhou Q, Jaworski J, Zhou Y, Valente D, Cotton J, Honey D, Boudanova E, Beninga J, Rao E, Wei R, Mauriac C, Pan C, Park A, Qiu H
OpenAccess logo MAbs 12 1814583
PMID: 32892677

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin gamma-1 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 25.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 227-449; Coverage: 50%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand BMA 1 x BMA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2221
Unit cell:
a: 52.091Å b: 142.504Å c: 75.235Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.221
Expression system: Homo sapiens

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Citations

1 review citation

Antibody-drug conjugates: the paradigm shifts in the targeted cancer therapy.
Aggarwal et al. (2023)
4 other articles

1 mention without citation

Engineered Fc-glycosylation switch to eliminate antibody effector function.
Zhou et al. (2020)

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