› 6x46

Solution NMR

NMR solution structure of Asterix/Gtsf1 from mouse (CHHC zinc finger domains)

Released:
DOI: 10.2210/pdb6x46/pdb
PDB entry 6x46 coloured by chain, ensemble of 20 models, front view.
PDB entry 6x46 coloured by chain, ensemble of 20 models, side view.
PDB entry 6x46 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
Ipsaro JJ, O'Brien PA, Bhattacharya S, Palmer AG, Joshua-Tor L
Cell Rep 34 108914 (2021)
PMID: 33789107

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190079 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gametocyte-specific factor 1 Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 14.22 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9DAN6 (Residues: 1-115; Coverage: 69%)
Gene names: Cue110, Fam112b, Gtsf1
Sequence domains: U11-48K-like CHHC zinc finger

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Mammalian antiviral systems directed by small RNA.
Takahashi et al. (2021)
1 more

2 mentions without citation

Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
Ipsaro et al. (2021)
1 more