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Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.22: Coagulation factor IXa

Reaction catalysed:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Alternative Name(s):
  • Activated Christmas factor
  • Activated blood coagulation factor XI
  • Activated blood-coagulation factor IX
  • Autoprothrombin II
  • Blood platelet cofactor II
  • Blood-coagulation factor IXa
  • Christmas factor

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF14670
Domain description: Coagulation Factor Xa inhibitory site
Occurring in:
  1. Coagulation factor IXa light chain
The deposited structure of PDB entry 6x5l contains 1 copy of Pfam domain PF14670 (Coagulation Factor Xa inhibitory site) in Coagulation factor IXa light chain. Showing 1 copy in chain B.

PF00089
Domain description: Trypsin
Occurring in:
  1. Coagulation factor IXa heavy chain
The deposited structure of PDB entry 6x5l contains 1 copy of Pfam domain PF00089 (Trypsin) in Coagulation factor IXa heavy chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Coagulation factor IXa heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Coagulation factor IXa heavy chain
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Coagulation factor IXa heavy chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Coagulation factor IXa heavy chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Coagulation factor IXa heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Coagulation factor IXa heavy chain

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