› 6x6k

Electron Microscopy
3.1Å resolution

Cryo-EM Structure of the Helicobacter pylori dCag3 OMC

Released:
DOI: 10.2210/pdb6x6k/pdb
PDB entry 6x6k coloured by chain, front view.
PDB entry 6x6k coloured by chain, side view.
PDB entry 6x6k coloured by chain, top view.
Source organism: Helicobacter pylori
Primary publication:
Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex.
Sheedlo MJ, Chung JM, Sawhney N, Durie CL, Cover TL, Ohi MD, Lacy DB
OpenAccess logo Elife 9 (2020)
PMID: 32876048
Related structures: EMD-22076

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 42-mer (preferred)
PDBe Complex ID:
PDB-CPX-245037 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cag12 Chains: AT, BT, CT, DT, ET, FT, GT, HT, IT, JT, KT, LT, MT, NT
Molecule details ›
Chains: AT, BT, CT, DT, ET, FT, GT, HT, IT, JT, KT, LT, MT, NT
Length: 278 amino acids
Theoretical weight: 32.23 KDa
Source organism: Helicobacter pylori
UniProt:
  • Canonical: Q6VRP0 (Residues: 1-278; Coverage: 99%)
Gene names: C2840_02765, C2842_02765, C2R60_07410, HP0532, SE88_02750, cag12, cagT
Sequence domains: Cag pathogenicity island protein Cag12
Type IV secretion system apparatus protein CagX Chains: AX, BX, CX, DX, EX, FX, GX, HX, IX, JX, KX, LX, MX, NX
Molecule details ›
Chains: AX, BX, CX, DX, EX, FX, GX, HX, IX, JX, KX, LX, MX, NX
Length: 522 amino acids
Theoretical weight: 60.72 KDa
Source organism: Helicobacter pylori
Cag pathogenicity island protein (Cag7) Chains: AY, BY, CY, DY, EY, FY, GY, HY, IY, JY, KY, LY, MY, NY
Molecule details ›
Chains: AY, BY, CY, DY, EY, FY, GY, HY, IY, JY, KY, LY, MY, NY
Length: 1927 amino acids
Theoretical weight: 219.75 KDa
Source organism: Helicobacter pylori
UniProt:
  • Canonical: O25262 (Residues: 1-1927; Coverage: 100%)
Gene name: HP_0527
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-22076

Quick links

Citations

7 review citations

Type IV secretion systems: Advances in structure, function, and activation.
Costa et al. (2021)
6 more

1 mention without citation

Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex.
Sheedlo et al. (2020)