6xa7

X-ray diffraction
2.5Å resolution

Crystal Structure of Human Scribble PDZ2:Vangl2 complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-171949 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein scribble homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 96 amino acids
Theoretical weight: 9.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14160 (Residues: 860-950; Coverage: 6%)
Gene names: CRIB1, KIAA0147, LAP4, SCRB1, SCRIB, VARTUL
Sequence domains: PDZ domain
Vang-like protein 2 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 8 amino acids
Theoretical weight: 920 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9ULK5 (Residues: 514-521; Coverage: 2%)
Gene names: KIAA1215, STB1, VANGL2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Unit cell:
a: 78.047Å b: 60.765Å c: 96.017Å
α: 90° β: 106.481° γ: 90°
R-values:
R R work R free
0.238 0.236 0.267
Expression systems:
  • Escherichia coli
  • Not provided