› 6xid

X-ray diffraction
1.48Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167777 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 31-152; Coverage: 18%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Proprotein convertase subtilisin/kexin type 9 Chain: B
Molecule details ›
Chain: B
Length: 308 amino acids
Theoretical weight: 32.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-452; Coverage: 45%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Subtilase family
Peptide 51 Chain: I
Molecule details ›
Chain: I
Length: 11 amino acids
Theoretical weight: 1.5 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
4 modified residues:
Ligand ZLF 1 x ZLF
Ligand DAL 1 x DAL
Ligand FTR 2 x FTR
Ligand 3WX 1 x 3WX

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3221
Unit cell:
a: 70.827Å b: 70.827Å c: 152.952Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.187 0.205
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

6 review citations

Directing evolution of novel ligands by mRNA display.
Kamalinia et al. (2021)
5 more

2 mentions without citation

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Johns et al. (2023)
1 more