› › Function and Biology

Human 20S proteasome bound to an engineered 11S (PA26) activator

Source organisms:
Biochemical function: protein binding
Biological process: proteolysis involved in protein catabolic process
Cellular component: proteasome complex

Quick links

EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. Proteasome subunit alpha type-6
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-4
  4. Proteasome subunit alpha type-7
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-1
  7. Proteasome subunit alpha type-3
  8. Proteasome subunit beta type-6
  9. Proteasome subunit beta type-7
  10. Proteasome subunit beta type-3
  11. Proteasome subunit beta type-2
  12. Proteasome subunit beta type-5
  13. Proteasome subunit beta type-1
  14. Proteasome subunit beta type-4
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-6. Showing 1 copy in chain A.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-2. Showing 1 copy in chain B.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-4. Showing 1 copy in chain C.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-7. Showing 1 copy in chain D.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-5. Showing 1 copy in chain E.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-1. Showing 1 copy in chain F.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-3. Showing 1 copy in chain G.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-6. Showing 1 copy in chain H.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-7. Showing 1 copy in chain I.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-3. Showing 1 copy in chain J.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-2. Showing 1 copy in chain K.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-5. Showing 1 copy in chain L.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-1. Showing 1 copy in chain M.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-4. Showing 1 copy in chain N.

PF02252
Domain description: Proteasome activator PA28, C-terminal
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
The deposited structure of PDB entry 6xmj contains 7 copies of Pfam domain PF02252 (Proteasome activator pa28 beta subunit) in Proteasome activator PA28 C-terminal domain-containing protein. Showing 1 copy in chain O.

PF10584
Domain description: Proteasome subunit A N-terminal signature
Occurring in:
  1. Proteasome subunit alpha type-6
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-4
  4. Proteasome subunit alpha type-7
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-1
  7. Proteasome subunit alpha type-3
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-6. Showing 1 copy in chain A.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-2. Showing 1 copy in chain B.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-4. Showing 1 copy in chain C.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-7. Showing 1 copy in chain D.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-5. Showing 1 copy in chain E.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-1. Showing 1 copy in chain F.
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF10584 (Proteasome subunit A N-terminal signature) in Proteasome subunit alpha type-3. Showing 1 copy in chain G.

PF12465
Domain description: Proteasome beta subunits C terminal
Occurring in:
  1. Proteasome subunit beta type-7
The deposited structure of PDB entry 6xmj contains 1 copy of Pfam domain PF12465 (Proteasome beta subunits C terminal ) in Proteasome subunit beta type-7. Showing 1 copy in chain I.

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Proteasome subunit alpha type-6
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-4
  4. Proteasome subunit alpha type-7
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-1
  7. Proteasome subunit alpha type-3
  8. Proteasome subunit beta type-6
  9. Proteasome subunit beta type-7
  10. Proteasome subunit beta type-3
  11. Proteasome subunit beta type-2
  12. Proteasome subunit beta type-5
  13. Proteasome subunit beta type-1
  14. Proteasome subunit beta type-4
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. Proteasome subunit alpha type-6
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-4
  4. Proteasome subunit alpha type-7
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-1
  7. Proteasome subunit alpha type-3
  8. Proteasome subunit beta type-6
  9. Proteasome subunit beta type-7
  10. Proteasome subunit beta type-3
  11. Proteasome subunit beta type-2
  12. Proteasome subunit beta type-5
  13. Proteasome subunit beta type-1
  14. Proteasome subunit beta type-4
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. Proteasome subunit beta type-6
  2. Proteasome subunit beta type-7
  3. Proteasome subunit beta type-3
  4. Proteasome subunit beta type-2
  5. Proteasome subunit beta type-5
  6. Proteasome subunit beta type-1
  7. Proteasome subunit beta type-4
IPR000243
Domain description: Peptidase T1A, proteasome beta-subunit
Occurring in:
  1. Proteasome subunit beta type-6
  2. Proteasome subunit beta type-7
  3. Proteasome subunit beta type-5
IPR016050
Domain description: Proteasome beta-type subunit, conserved site
Occurring in:
  1. Proteasome subunit alpha type-4
  2. Proteasome subunit beta type-6
  3. Proteasome subunit beta type-7
  4. Proteasome subunit beta type-3
  5. Proteasome subunit beta type-2
  6. Proteasome subunit beta type-5
  7. Proteasome subunit beta type-1
  8. Proteasome subunit beta type-4
IPR003186
Domain description: Proteasome activator PA28, C-terminal domain
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR036252
Domain description: Proteasome activator superfamily
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR036997
Domain description: Proteasome activator PA28, C-terminal domain superfamily
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR023332
Domain description: Proteasome alpha-type subunit
Occurring in:
  1. Proteasome subunit alpha type-6
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-4
  4. Proteasome subunit alpha type-7
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-1
  7. Proteasome subunit alpha type-3
IPR000426
Domain description: Proteasome alpha-subunit, N-terminal domain
Occurring in:
  1. Proteasome subunit alpha type-6
  2. Proteasome subunit alpha type-2
  3. Proteasome subunit alpha type-4
  4. Proteasome subunit alpha type-7
  5. Proteasome subunit alpha type-5
  6. Proteasome subunit alpha type-1
  7. Proteasome subunit alpha type-3
IPR016295
Domain description: Proteasome subunit beta 4
Occurring in:
  1. Proteasome subunit beta type-4
IPR035206
Domain description: Proteasome subunit beta 2
Occurring in:
  1. Proteasome subunit beta type-2
IPR033811
Domain description: Proteasome beta 3 subunit
Occurring in:
  1. Proteasome subunit beta type-3
IPR024689
Domain description: Proteasome beta subunit, C-terminal
Occurring in:
  1. Proteasome subunit beta type-7
IPR035144
Domain description: Proteasome subunit alpha 1
Occurring in:
  1. Proteasome subunit alpha type-1
IPR033812
Domain description: Proteasome subunit alpha5
Occurring in:
  1. Proteasome subunit alpha type-5
IPR034642
Domain description: Proteasome subunit alpha6
Occurring in:
  1. Proteasome subunit alpha type-6

Quick links