› 6xo1

X-ray diffraction
1.76Å resolution

Crystal structure of N97A mutant of human CEACAM1

Released:
DOI: 10.2210/pdb6xo1/pdb
PDB entry 6xo1 coloured by chain, front view.
PDB entry 6xo1 coloured by chain, side view.
PDB entry 6xo1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.
Gandhi AK, Sun ZJ, Kim WM, Huang YH, Kondo Y, Bonsor DA, Sundberg EJ, Wagner G, Kuchroo VK, Petsko GA, Blumberg RS
OpenAccess logo Commun Biol 4 360 (2021)
PMID: 33742094

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-537347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell adhesion molecule CEACAM1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13688 (Residues: 35-141; Coverage: 22%)
Gene names: BGP, BGP1, CEACAM1
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

1 bound ligand:
Ligand MLA 2 x MLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-1
Spacegroup: C2221
Unit cell:
a: 55.934Å b: 56.879Å c: 124.541Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.24
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Human CEACAM1 N-domain dimerization is independent from glycan modifications.
Belcher Dufrisne et al. (2022)
4 more

2 mentions without citation

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.
Gandhi et al. (2021)
1 more