› 6xtb

Electron Microscopy
4.3Å resolution

Subunit BBS 5 of the human core BBSome complex

Released:
DOI: 10.2210/pdb6xtb/pdb
PDB entry 6xtb coloured by chain, front view.
PDB entry 6xtb coloured by chain, side view.
PDB entry 6xtb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human BBSome core complex.
Klink BU, Gatsogiannis C, Hofnagel O, Wittinghofer A, Raunser S
OpenAccess logo Elife 9 (2020)
PMID: 31951201
Related structures: EMD-10618

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185377 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BBSome complex member BBS5 Chain: E
Molecule details ›
Chain: E
Length: 341 amino acids
Theoretical weight: 38.8 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8N3I7 (Residues: 1-341; Coverage: 100%)
Gene name: BBS5
Sequence domains: Bardet-Biedl syndrome 5 protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.3Å
Relevant EMDB volumes: EMD-10618
Expression system: Trichoplusia ni

Quick links

Citations

13 review citations

Intraflagellar transport trains and motors: Insights from structure.
Webb et al. (2020)
12 more

1 mention without citation

Ubiquitylation of BBSome is required for ciliary assembly and signaling.
Chiuso et al. (2023)