› 6xti

Solution NMR

NMR solution structure of class IV lasso peptide felipeptin A2 from Amycolatopsis sp. YIM10

Released:
DOI: 10.2210/pdb6xti/pdb
PDB entry 6xti coloured by chain, ensemble of 20 models, front view.
PDB entry 6xti coloured by chain, ensemble of 20 models, side view.
PDB entry 6xti coloured by chain, ensemble of 20 models, top view.
Source organism: Amycolatopsis sp.
Primary publication:
Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin.
Guerrero-Garzón JF, Madland E, Zehl M, Singh M, Rezaei S, Aachmann FL, Courtade G, Urban E, Rückert C, Busche T, Kalinowski J, Cao YR, Jiang Y, Jiang CL, Selivanova G, Zotchev SB
OpenAccess logo iScience 23 101785 (2020)
PMID: 33294793

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105474 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lasso RiPP family leader peptide-containing protein Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.87 KDa
Source organism: Amycolatopsis sp.
Expression system: Streptomyces coelicolor
UniProt:
  • Canonical: A0A5P9PSL4 (Residues: 25-41; Coverage: 42%)
Gene name: YIM_29265

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: simulated annealing
Expression system: Streptomyces coelicolor

Quick links

Citations

3 review citations

New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining.
Caffrey et al. (2022)
2 more

1 mention without citation

Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin.
Guerrero-Garzón et al. (2020)