› 6xwl

X-ray diffraction
3.2Å resolution

Function and Biology Details

Reaction catalysed: 
L-serine + L-homocysteine = L-cystathionine + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystathionine beta-synthase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 514 amino acids
Theoretical weight: 55.96 KDa
Source organism: Toxoplasma gondii ME49
Expression system: Toxoplasma gondii ME49
UniProt:
  • Canonical: A0A125YSJ9 (Residues: 1-514; Coverage: 100%)
Gene name: TGME49_259180
Sequence domains:

Ligands and Environments


Cofactor: Ligand PLP 6 x PLP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P31
Unit cell:
a: 83.237Å b: 83.237Å c: 420.309Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.253 0.277
Expression system: Toxoplasma gondii ME49

Quick links

Citations

2 citation in other articles

H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine.
Petrosino et al. (2022)
1 more

1 mention without citation

Insights into Domain Organization and Regulatory Mechanism of Cystathionine Beta-Synthase from Toxoplasma gondii.
Conter et al. (2022)