PDB 6xyo structure summary ‹ Protein Data Bank in Europe (PDBe)

Electron Microscopy

2.6Å resolution

Multiple system atrophy Type I alpha-synuclein filament

Released: 12 Feb 2020

DOI: 10.2210/pdb6xyo/pdb

Source organism: Homo sapiens

Primary publication:
Structures of α-synuclein filaments from multiple system atrophy.

Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M

Nature 585 464-469 (2020)

PMID: 32461689

Related structures: EMD-10650

Function and Biology Details

Biochemical function:

cuprous ion binding

Biological process:

regulation of reactive oxygen species metabolic process

Cellular component:

supramolecular fiber

Sequence domains:

Structure analysis Details

Assembly composition:

homo decamer (preferred)

Assembly name:

Alpha-synuclein (preferred)

PDBe Complex ID:

PDB-CPX-153502 (preferred)

Entry contents:

1 distinct polypeptide molecule

Macromolecule:

Alpha-synuclein Chains: A, B, C, D, E, F, G, H, I, J

Molecule details ›

Chains: A, B, C, D, E, F, G, H, I, J
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
UniProt: