› 6y0m

X-ray diffraction
1.5Å resolution

Crystal structure of human CD23 lectin domain N225D, K229E, S252N, T251N mutant

Released:
DOI: 10.2210/pdb6y0m/pdb
Model geometry
Fit model/data
PDB entry 6y0m coloured by chain, front view.
PDB entry 6y0m coloured by chain, side view.
PDB entry 6y0m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
Ilkow VF, Davies AM, Dhaliwal B, Beavil AJ, Sutton BJ, McDonnell JM
OpenAccess logo FEBS Open Bio 11 1827-1840 (2021)
PMID: 34075727

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low affinity immunoglobulin epsilon Fc receptor soluble form Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 16.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06734 (Residues: 156-298; Coverage: 45%)
Gene names: CD23A, CLEC4J, FCE2, FCER2, IGEBF
Sequence domains: Lectin C-type domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P622
Unit cell:
a: 115.186Å b: 115.186Å c: 45.752Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.17 0.168 0.212
Expression system: Escherichia coli

Quick links

Citations

1 review citation

On the complexity of IgE: The role of structural flexibility and glycosylation for binding its receptors.
Plattner et al. (2023)

1 mention without citation

Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
Ilkow et al. (2021)