› 6y1u

X-ray diffraction
1.68Å resolution

Mycobacterium tuberculosis FtsZ-GDP in complex with 4-hydroxycoumarin

Released:
DOI: 10.2210/pdb6y1u/pdb
PDB entry 6y1u coloured by chain, front view.
PDB entry 6y1u coloured by chain, side view.
PDB entry 6y1u coloured by chain, top view.
Source organism: Mycobacterium tuberculosis CDC1551
Primary publication:
Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ.
Alnami A, Norton RS, Pena HP, Haider S, Kozielski F
J Mol Biol 433 167061 (2021)
PMID: 34023403

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161841 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein FtsZ Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 32.08 KDa
Source organism: Mycobacterium tuberculosis CDC1551
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WN95 (Residues: 1-314; Coverage: 83%)
Gene names: MTCY270.18, Rv2150c, ftsZ
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand DMS 21 x DMS
Ligand GDP 1 x GDP
Ligand 4HC 2 x 4HC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P65
Unit cell:
a: 88.13Å b: 88.13Å c: 176.783Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.17 0.168 0.197
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites.
Andreu et al. (2022)
2 more

1 mention without citation

Investigating the Antituberculosis Activity of Selected Commercial Essential Oils and Identification of Active Constituents Using a Biochemometrics Approach and In Silico Modeling.
Boussamba-Digombou et al. (2022)