› 6y21

X-ray diffraction
3.6Å resolution

Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-Cystathionine

Released:
DOI: 10.2210/pdb6y21/pdb
PDB entry 6y21 coloured by chain, front view.
PDB entry 6y21 coloured by chain, side view.
PDB entry 6y21 coloured by chain, top view.
Source organism: Toxoplasma gondii ME49
Entry authors: Fernandez-Rodriguez C, Oyenarte I, Conter C, Gonzalez-Recio I, Quintana I, Martinez-Chantar M, Astegno A, Martinez-Cruz LA

Function and Biology Details

Reaction catalysed: 
L-serine + L-homocysteine = L-cystathionine + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystathionine beta-synthase Chains: A, B, D
Molecule details ›
Chains: A, B, D
Length: 514 amino acids
Theoretical weight: 55.96 KDa
Source organism: Toxoplasma gondii ME49
Expression system: Toxoplasma gondii ME49
UniProt:
  • Canonical: A0A125YSJ9 (Residues: 1-514; Coverage: 100%)
Gene name: TGME49_259180
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand P1T 3 x P1T
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P3121
Unit cell:
a: 83.006Å b: 83.006Å c: 421.373Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.264 0.263 0.29
Expression system: Toxoplasma gondii ME49

Quick links