› 6y4n

X-ray diffraction
2.85Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-236972 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Tubulin alpha-1B chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 451 amino acids
Theoretical weight: 50.2 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q2XVP4 (Residues: 1-451; Coverage: 100%)
Gene name: TUBA1B
Sequence domains:
Tubulin beta chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 445 amino acids
Theoretical weight: 49.91 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P02554 (Residues: 1-445; Coverage: 100%)
Sequence domains:
Stathmin-4 Chain: E
Tubulin-Tyrosine Ligase Chain: F

Ligands and Environments

13 bound ligands:
Ligand GTP 3 x GTP
Ligand MG 5 x MG
Ligand CA 2 x CA
Ligand GDP 1 x GDP
Ligand MES 1 x MES
Ligand O9B 1 x O9B
Ligand O9K 1 x O9K
Ligand O9N 1 x O9N
Ligand PGE 1 x PGE
Ligand VAL 1 x VAL
Ligand P6S 1 x P6S
Ligand PEG 1 x PEG
Ligand ACP 1 x ACP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 104.284Å b: 154.969Å c: 183.433Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.22
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Tubulysins are Essential for the Preying of Ciliates by Myxobacteria.
Yu et al. (2023)

1 mention without citation

Antibody-drug conjugates: Recent advances in payloads.
Wang et al. (2023)

PDB-REDO

The sliders below show the change in model quality between original PDB entry and the PDB-REDO entry

Model Geometry
 
 
Data not available
DNA/RNA Geometry
 
 
Data not available
Fit model/data
 
 
Data not available
PDB-REDO