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Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)

Source organism: Homo sapiens
Biochemical function: protein heterodimerization activity
Biological process: not assigned
Cellular component: nucleosome

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EC 2.7.7.86: Cyclic GMP-AMP synthase

Reaction catalysed:
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Systematic name:
ATP:GTP adenylyltransferase (cyclizing)
Alternative Name(s):
  • CGAMP synthase
  • CGAS

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.2
  2. Histone H2A type 2-C
  3. Histone H2B type 1-K
  4. Histone H2A type 2-C
  5. Histone H2B type 1-K
The deposited structure of PDB entry 6y5e contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.2. Showing 1 copy in chain A.
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 2-C. Showing 1 copy in chain C.
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 1-K. Showing 1 copy in chain D.
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 2-C. Showing 1 copy in chain G.
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 1-K. Showing 1 copy in chain H.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 2-C
  2. Histone H2A type 2-C
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 2-C. Showing 1 copy in chain C.
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 2-C. Showing 1 copy in chain G.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
  2. Histone H4
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain B.
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain F.

PF20266
Domain description: Mab-21 protein HhH/H2TH-like domain
Occurring in:
  1. Cyclic GMP-AMP synthase
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF20266 (Mab-21 protein HhH/H2TH-like domain) in Cyclic GMP-AMP synthase. Showing 1 copy in chain K.

PF03281
Domain description: Mab-21 protein nucleotidyltransferase domain
Occurring in:
  1. Cyclic GMP-AMP synthase
The deposited structure of PDB entry 6y5e contains 1 copy of Pfam domain PF03281 (Mab-21 protein nucleotidyltransferase domain) in Cyclic GMP-AMP synthase. Showing 1 copy in chain K.

InterPro InterPro annotations
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3.2
  2. Histone H4
  3. Histone H2A type 2-C
  4. Histone H2B type 1-K
  5. Histone H4
  6. Histone H2A type 2-C
  7. Histone H2B type 1-K
IPR000558
Domain description: Histone H2B
Occurring in:
  1. Histone H2B type 1-K
  2. Histone H2B type 1-K
IPR002119
Domain description: Histone H2A
Occurring in:
  1. Histone H2A type 2-C
  2. Histone H2A type 2-C
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
  2. Histone H4
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3.2
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3.2
  2. Histone H2A type 2-C
  3. Histone H2B type 1-K
  4. Histone H2A type 2-C
  5. Histone H2B type 1-K
IPR032454
Domain description: Histone H2A, C-terminal domain
Occurring in:
  1. Histone H2A type 2-C
  2. Histone H2A type 2-C
IPR032458
Domain description: Histone H2A conserved site
Occurring in:
  1. Histone H2A type 2-C
  2. Histone H2A type 2-C
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
  2. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
  2. Histone H4
IPR046906
Domain description: Mab-21-like, HhH/H2TH-like domain
Occurring in:
  1. Cyclic GMP-AMP synthase
IPR046903
Domain description: Mab-21-like, nucleotidyltransferase domain
Occurring in:
  1. Cyclic GMP-AMP synthase
IPR024810
Domain description: MAB21L/Cyclic GMP-AMP synthase-like receptor
Occurring in:
  1. Cyclic GMP-AMP synthase

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