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Crystal structure of SNAP-tag labeled with a benzyl-tetramethylrhodamine fluorophore

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: methylation
Cellular component: nucleus

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EC 2.1.1.63: Methylated-DNA--[protein]-cysteine S-methyltransferase

Reaction catalysed:
DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
Systematic name:
DNA-6-O-methylguanine/DNA-4-O-methylthymine:[protein]-L-cysteine S-methyltransferase
Alternative Name(s):
  • 6-O-methylguanine-DNA methyltransferase
  • Ada (gene name)
  • MGMT (gene name)
  • MGT1 (gene name)
  • O-6-methylguanine-DNA-alkyltransferase
  • Ogt (gene name)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01035
Domain description: 6-O-methylguanine DNA methyltransferase, DNA binding domain
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase
The deposited structure of PDB entry 6y8p contains 1 copy of Pfam domain PF01035 (6-O-methylguanine DNA methyltransferase, DNA binding domain) in Methylated-DNA--protein-cysteine methyltransferase. Showing 1 copy in chain A.

PF02870
Domain description: 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase
The deposited structure of PDB entry 6y8p contains 1 copy of Pfam domain PF02870 (6-O-methylguanine DNA methyltransferase, ribonuclease-like domain) in Methylated-DNA--protein-cysteine methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014048
Domain description: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase
IPR001497
Domain description: Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase
IPR036217
Domain description: Methylated DNA-protein cysteine methyltransferase, DNA binding domain
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase
IPR036631
Domain description: Methylated DNA-protein cysteine methyltransferase domain superfamily
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase
IPR008332
Domain description: Methylguanine DNA methyltransferase, ribonuclease-like domain
Occurring in:
  1. Methylated-DNA--protein-cysteine methyltransferase

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