› 6yax

X-ray diffraction
2.8Å resolution

Crystal structure of CD32b (Fc Gamma Receptor IIb) in complex with Human IgG1 Fab fragment (5C05)

Released:
DOI: 10.2210/pdb6yax/pdb
PDB entry 6yax coloured by chain, front view.
PDB entry 6yax coloured by chain, side view.
PDB entry 6yax coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Fisher H, Tews I, Orr C

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211055 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
5C05 F(ab) heavy chain Chains: HHH, III
Molecule details ›
Chains: HHH, III
Length: 218 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
5C05 F(ab) light chain Chains: LLL, MMM
Molecule details ›
Chains: LLL, MMM
Length: 218 amino acids
Theoretical weight: 22.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Low affinity immunoglobulin gamma Fc region receptor II-c Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 181 amino acids
Theoretical weight: 20.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31995 (Residues: 43-217; Coverage: 62%)
Gene names: CD32, FCG2, FCGR2C, IGFR2
Sequence domains: Immunoglobulin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand PG4 2 x PG4
Ligand NAG 1 x NAG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: P43
Unit cell:
a: 95.728Å b: 95.728Å c: 186.038Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.264
Expression system: Homo sapiens

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