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Cryo-EM structure of T7 bacteriophage DNA translocation gp15-gp16 core complex intermediate assembly

Source organism: Escherichia phage T7
Biochemical function: lyase activity
Biological process: symbiont genome ejection through host cell envelope, short tail mechanism
Cellular component: virion component

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EC 4.2.2.n1: Peptidoglycan lytic exotransglycosylase

Reaction catalysed:
Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
Systematic name:
Peptidoglycan lytic exotransglycosylase
Alternative Name(s):
  • Exomuramidase
  • MltF
  • Murein lyase F

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01464
Domain description: Transglycosylase SLT domain
Occurring in:
  1. Peptidoglycan transglycosylase gp16
The deposited structure of PDB entry 6yt5 contains 6 copies of Pfam domain PF01464 (Transglycosylase SLT domain) in Peptidoglycan transglycosylase gp16. Showing 1 copy in chain G.

InterPro InterPro annotations
IPR000189
Domain description: Prokaryotic transglycosylase, active site
Occurring in:
  1. Peptidoglycan transglycosylase gp16
IPR008258
Domain description: Transglycosylase SLT domain 1
Occurring in:
  1. Peptidoglycan transglycosylase gp16
IPR038994
Domain description: Internal virion protein Gp16
Occurring in:
  1. Peptidoglycan transglycosylase gp16
IPR023346
Domain description: Lysozyme-like domain superfamily
Occurring in:
  1. Peptidoglycan transglycosylase gp16
IPR038993
Domain description: Internal virion protein Gp15
Occurring in:
  1. Internal virion protein gp15

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