› 6ytl

Electron Microscopy
3.82Å resolution

Cryo-EM structure of a dimer of undecameric human CALHM4 in the absence of Ca2+

Released:
DOI: 10.2210/pdb6ytl/pdb
PDB entry 6ytl coloured by chain, front view.
PDB entry 6ytl coloured by chain, side view.
PDB entry 6ytl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures and functional properties of CALHM channels of the human placenta.
Drożdżyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R
OpenAccess logo Elife 9 (2020)
PMID: 32374262
Related structures: EMD-10919

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo 22-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177344 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium homeostasis modulator protein 4 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V
Length: 314 amino acids
Theoretical weight: 35.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5JW98 (Residues: 1-314; Coverage: 100%)
Gene names: C6orf78, CALHM4, FAM26D, UNQ6481/PRO21277
Sequence domains: Calcium homeostasis modulator

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.82Å
Relevant EMDB volumes: EMD-10919
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Taste transduction and channel synapses in taste buds.
Taruno et al. (2021)
1 more

3 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
2 more