› 6yvr

X-ray diffraction
2.46Å resolution

Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13

Released:
DOI: 10.2210/pdb6yvr/pdb
PDB entry 6yvr coloured by chain, front view.
PDB entry 6yvr coloured by chain, side view.
PDB entry 6yvr coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A
OpenAccess logo Sci Adv 7 (2021)
PMID: 33571132

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149056 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neurotensin receptor type 1 Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 482 amino acids
Theoretical weight: 53.09 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P20789 (Residues: 50-371; Coverage: 72%)
Gene names: Ntsr, Ntsr1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
neurotensin NTS8-13 (full agonist) Chains: CCC, DDD
Molecule details ›
Chains: CCC, DDD
Length: 8 amino acids
Theoretical weight: 933 Da
Source organism: Rattus norvegicus
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand BNG 8 x BNG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 89.886Å b: 114.001Å c: 195.424Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.238
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Ligands of Adrenergic Receptors: A Structural Point of View.
Wu et al. (2021)
2 more

3 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
2 more