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Structure of Cathepsin S in complex with Compound 2

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.27: Cathepsin S

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin S
The deposited structure of PDB entry 6yyp contains 2 copies of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin S. Showing 1 copy in chain B [auth BBB].

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin S
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin S
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin S
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Cathepsin S
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin S
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Cathepsin S
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin S

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