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tRNA-Guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Source organism: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
Biochemical function: metal ion binding
Biological process: tRNA-guanine transglycosylation
Cellular component: not assigned

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EC 2.4.2.29: tRNA-guanosine(34) preQ(1) transglycosylase

Reaction catalysed:
Guanine(34) in tRNA + 7-aminomethyl-7-carbaguanine = 7-aminomethyl-7-carbaguanine(34) in tRNA + guanine
Systematic name:
tRNA-guanosine(34):7-aminomethyl-7-deazaguanine tRNA-D-ribosyltransferase
Alternative Name(s):
  • Guanine insertion enzyme
  • Q-insertase
  • TGT
  • Transfer ribonucleate glycosyltransferase
  • Transfer ribonucleic acid guanine(34) transglycosylase
  • tRNA guanine(34) transglycosidase
  • tRNA transglycosylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01702
Domain description: Queuine tRNA-ribosyltransferase
Occurring in:
  1. Queuine tRNA-ribosyltransferase
The deposited structure of PDB entry 6yyz contains 1 copy of Pfam domain PF01702 (Queuine tRNA-ribosyltransferase) in Queuine tRNA-ribosyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002616
Domain description: tRNA-guanine(15) transglycosylase-like
Occurring in:
  1. Queuine tRNA-ribosyltransferase
IPR004803
Domain description: tRNA-guanine transglycosylase
Occurring in:
  1. Queuine tRNA-ribosyltransferase
IPR036511
Domain description: Queuine tRNA-ribosyltransferase-like
Occurring in:
  1. Queuine tRNA-ribosyltransferase

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