Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- FATC domain
- Phosphatidylinositol 3/4-kinase, conserved site
- UME domain
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- Protein kinase-like domain superfamily
- Tetratricopeptide-like helical domain superfamily
- PIK-related kinase, FAT
3 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
ATR-ATRIP DNA damage-sensing kinase complex (preferred)
PDBe Complex ID:
PDB-CPX-153548 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA damage checkpoint protein LCD1
Molecule details ›
Chains: C, D
Length: 747 amino acids
Theoretical weight: 86.53 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: DNA damage checkpoint protein
Length: 747 amino acids
Theoretical weight: 86.53 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
Q04377 (Residues: 1-747; Coverage: 100%)
Sequence domains: DNA damage checkpoint protein
Serine/threonine-protein kinase MEC1
Molecule details ›
