Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- ER membrane protein complex subunit 8/9
- ER membrane protein complex subunit 4
- Tetratricopeptide repeat
- Tetratricopeptide-like helical domain superfamily
- MPN domain
- ER membrane protein complex subunit 7, beta-sandwich domain
- Carbohydrate-binding-like fold
- ER membrane protein complex subunit 7
6 more domains
Structure analysis Details
Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172151 (preferred)
Entry contents:
9 distinct polypeptide molecules
Macromolecules (9 distinct):
ER membrane protein complex subunit 1
Molecule details ›
Chain: A
Length: 993 amino acids
Theoretical weight: 86.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Length: 993 amino acids
Theoretical weight: 86.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q8N766 (Residues: 482-510, 960-993; Coverage: 7%)
ER membrane protein complex subunit 2
Molecule details ›
Chain: B
Length: 297 amino acids
Theoretical weight: 34.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: EMC2 TPR-like repeat domain
Length: 297 amino acids
Theoretical weight: 34.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q15006 (Residues: 1-297; Coverage: 100%)
Sequence domains: EMC2 TPR-like repeat domain
ER membrane protein complex subunit 3
Molecule details ›
Chain: C
Length: 261 amino acids
Theoretical weight: 29.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Integral membrane protein EMC3/TMCO1-like
Length: 261 amino acids
Theoretical weight: 29.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9P0I2 (Residues: 1-261; Coverage: 100%)
Sequence domains: Integral membrane protein EMC3/TMCO1-like
ER membrane protein complex subunit 4
Molecule details ›
Chain: D
Length: 183 amino acids
Theoretical weight: 20.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Protein of unknown function (DUF1077)
Length: 183 amino acids
Theoretical weight: 20.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q5J8M3 (Residues: 1-183; Coverage: 100%)
Sequence domains: Protein of unknown function (DUF1077)
ER membrane protein complex subunit 5
Molecule details ›
Chain: E
Length: 131 amino acids
Theoretical weight: 14.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Membrane magnesium transporter
Length: 131 amino acids
Theoretical weight: 14.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8N4V1 (Residues: 1-131; Coverage: 100%)
Sequence domains: Membrane magnesium transporter
ER membrane protein complex subunit 6
Molecule details ›
Chain: F
Length: 110 amino acids
Theoretical weight: 12.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: EMC6
Length: 110 amino acids
Theoretical weight: 12.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9BV81 (Residues: 1-110; Coverage: 100%)
Sequence domains: EMC6
Endoplasmic reticulum membrane protein complex subunit 7
Molecule details ›
Chain: G
Length: 242 amino acids
Theoretical weight: 26.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: ER membrane protein complex subunit 7, beta-sandwich domain
Length: 242 amino acids
Theoretical weight: 26.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9NPA0 (Residues: 1-242; Coverage: 100%)
Sequence domains: ER membrane protein complex subunit 7, beta-sandwich domain
ER membrane protein complex subunit 9
Molecule details ›
Chain: H
Length: 208 amino acids
Theoretical weight: 23.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Uncharacterised protein family (UPF0172)
Length: 208 amino acids
Theoretical weight: 23.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9Y3B6 (Residues: 1-208; Coverage: 100%)
Sequence domains: Uncharacterised protein family (UPF0172)
ER membrane protein complex subunit 10
Molecule details ›
Chain: I
Length: 262 amino acids
Theoretical weight: 27.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: ER membrane protein complex subunit 10
Length: 262 amino acids
Theoretical weight: 27.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q5UCC4 (Residues: 1-262; Coverage: 100%)
Sequence domains: ER membrane protein complex subunit 10
