› 6z3z

Electron Microscopy
3.19Å resolution

CryoEM structure of horse sodium/proton exchanger NHE9 without C-terminal regulatory domain in an inward-facing conformation

Released:
DOI: 10.2210/pdb6z3z/pdb
PDB entry 6z3z coloured by chain, front view.
PDB entry 6z3z coloured by chain, side view.
PDB entry 6z3z coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.
Winklemann I, Matsuoka R, Meier PF, Shutin D, Zhang C, Orellana L, Sexton R, Landreh M, Robinson CV, Beckstein O, Drew D
OpenAccess logo EMBO J 39 e105908 (2020)
PMID: 33118634
Related structures: EMD-11067

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123659 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/hydrogen exchanger 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 469 amino acids
Theoretical weight: 52.57 KDa
Source organism: Equus caballus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: F7B113 (Residues: 20-481; Coverage: 72%)
Gene names: NHE9, SLC9A9
Sequence domains: Sodium/hydrogen exchanger family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.19Å
Relevant EMDB volumes: EMD-11067
Expression system: Saccharomyces cerevisiae

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Citations

7 review citations

Intracellular pH Control by Membrane Transport in Mammalian Cells. Insights Into the Selective Advantages of Functional Redundancy.
Doyen et al. (2022)
6 more

4 mentions without citation

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.
Winklemann et al. (2020)
3 more