› 6z4s

X-ray diffraction
2.71Å resolution

Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule inverse agonist SR48692

Released:
DOI: 10.2210/pdb6z4s/pdb
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PDB entry 6z4s coloured by chain, front view.
PDB entry 6z4s coloured by chain, side view.
PDB entry 6z4s coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A
OpenAccess logo Sci Adv 7 (2021)
PMID: 33571132

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149054 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotensin receptor type 1 Chain: AAA
Molecule details ›
Chain: AAA
Length: 482 amino acids
Theoretical weight: 53.15 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P20789 (Residues: 50-371; Coverage: 72%)
Gene names: Ntsr, Ntsr1
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
Ligand Q6Q 1 x Q6Q
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 43.518Å b: 77.727Å c: 158.394Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.274 0.273 0.289
Expression system: Escherichia coli

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Citations

3 review citations

Ligands of Adrenergic Receptors: A Structural Point of View.
Wu et al. (2021)
2 more

2 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
1 more

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