› 6z54

X-ray diffraction
1.73Å resolution

Crystal structure of CLK3 in complex with macrocycle ODS2003178

Released:
DOI: 10.2210/pdb6z54/pdb
PDB entry 6z54 coloured by chain, front view.
PDB entry 6z54 coloured by chain, side view.
PDB entry 6z54 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Benderitter P, Hoflack J, Denis A, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156013 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein kinase CLK3 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 42.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49761 (Residues: 127-484; Coverage: 73%)
Gene name: CLK3
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand EDO 13 x EDO
Ligand PO4 1 x PO4
Ligand Q7H 1 x Q7H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 88.76Å b: 62.26Å c: 75.7Å
α: 90° β: 97.61° γ: 90°
R-values:
R R work R free
0.163 0.161 0.196
Expression system: Escherichia coli BL21(DE3)

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