› 6z84

X-ray diffraction
2.5Å resolution

CK2 alpha bound to chemical probe SGC-CK2-1 derivative

Released:
DOI: 10.2210/pdb6z84/pdb
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PDB entry 6z84 coloured by chain, front view.
PDB entry 6z84 coloured by chain, side view.
PDB entry 6z84 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD
Cell Chem Biol 28 546-558.e10 (2021)
PMID: 33484635

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 338 amino acids
Theoretical weight: 40.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-337; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand SO4 12 x SO4
Ligand QB8 2 x QB8
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 126.352Å b: 126.352Å c: 124.514Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.25
Expression system: Escherichia coli

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Citations

9 review citations

CK2 Regulation: Perspectives in 2021.
Roffey et al. (2021)
8 more

1 mention without citation

Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Wells et al. (2021)

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