› 6z8g

X-ray diffraction
1.56Å resolution

Crystal structure of VSG13 soaked in 0.5 M used to phase VSG13 to solve the structure.

Released:
DOI: 10.2210/pdb6z8g/pdb
PDB entry 6z8g coloured by chain, front view.
PDB entry 6z8g coloured by chain, side view.
PDB entry 6z8g coloured by chain, top view.
Source organism: Trypanosoma brucei
Primary publication:
Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Zeelen J, van Straaten M, Verdi J, Hempelmann A, Hashemi H, Perez K, Jeffrey PD, Hälg S, Wiedemar N, Mäser P, Papavasiliou FN, Stebbins CE
OpenAccess logo Nat Microbiol 6 392-400 (2021)
PMID: 33462435

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Variant surface glycoprotein MITat 1.13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 499 amino acids
Theoretical weight: 53.77 KDa
Source organism: Trypanosoma brucei
UniProt:
  • Canonical: Q58NS4 (Residues: 1-499; Coverage: 100%)
Gene name: MITat 1.13
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Ligand NAG 4 x NAG
Ligand BMA 2 x BMA
Ligand MAN 2 x MAN
2 bound ligands:
Ligand BR 23 x BR
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 74.148Å b: 68.407Å c: 157.759Å
α: 90° β: 92.17° γ: 90°
R-values:
R R work R free
0.226 0.226 0.233

Quick links

Citations

4 review citations

Learning from Yeast about Mitochondrial Carriers.
Mentel et al. (2021)
3 more