› 6z8h

X-ray diffraction
1.38Å resolution

Crystal structure of Variant Surface Glycoprotein VSG13

Released:
DOI: 10.2210/pdb6z8h/pdb
PDB entry 6z8h coloured by chain, front view.
PDB entry 6z8h coloured by chain, side view.
PDB entry 6z8h coloured by chain, top view.
Source organism: Trypanosoma brucei
Primary publication:
Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Zeelen J, van Straaten M, Verdi J, Hempelmann A, Hashemi H, Perez K, Jeffrey PD, Hälg S, Wiedemar N, Mäser P, Papavasiliou FN, Stebbins CE
Nat Microbiol 6 392-400 (2021)
PMID: 33462435

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Variant surface glycoprotein MITat 1.13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 499 amino acids
Theoretical weight: 53.77 KDa
Source organism: Trypanosoma brucei
UniProt:
  • Canonical: Q58NS4 (Residues: 1-499; Coverage: 100%)
Gene name: MITat 1.13
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 4 x NAG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 73.717Å b: 68.341Å c: 156.903Å
α: 90° β: 92.548° γ: 90°
R-values:
R R work R free
0.218 0.218 0.241

Quick links

Citations

4 review citations

The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids.
Borges et al. (2021)
3 more