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La Crosse virus polymerase at elongation mimicking stage

Electron Microscopy
3.02Å resolution
PDB entry 6z8k coloured by chain, front view.
PDB entry 6z8k coloured by chain, side view.
PDB entry 6z8k coloured by chain, top view.
Source organism: Orthobunyavirus lacrosseense
Assembly composition:
hetero hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule
3 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RNA-directed RNA polymerase L and RNA
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Multimeric state: hetero hexamer
Accessible surface area: 90804.71 Å2
Buried surface area: 11915.41 Å2
Dissociation area: 356.19 Å2
Dissociation energy (ΔGdiss): 0.52 kcal/mol
Dissociation entropy (TΔSdiss): 7.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-107612

Macromolecules

RNA-directed RNA polymerase L
Chain: A
Length: 2285 amino acids
Theoretical weight: 266.05 KDa
Source organism: Orthobunyavirus lacrosseense
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A5HC98 (Residues: 1-2263; Coverage: 100%)
Gene name: L
Pfam:
InterPro:
RNA-directed RNA polymerase L in PDB entry 6z8k, assembly 1, front view.
RNA-directed RNA polymerase L in PDB entry 6z8k, assembly 1, side view.
RNA-directed RNA polymerase L in PDB entry 6z8k, assembly 1, top view.
PDBe-KB: UniProt Coverage View: A5HC98  
122852004006008001,0001,2001,4001,6001,8002,0002,200
 
10002000
UniProt
A5HC98
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Sequence conservation
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RNA chains C, T
Name: La Crosse virus 5' vRNA 1-10
Representative chains: C, T
Source organism: Orthobunyavirus lacrosseense [3052409]
Expression system: Not provided
Length: 10 nucleotides
Theoretical weight: 3.22 KDa
La Crosse virus 5' vRNA 1-10 in PDB entry 6z8k, assembly 1, front view.
La Crosse virus 5' vRNA 1-10 in PDB entry 6z8k, assembly 1, side view.
La Crosse virus 5' vRNA 1-10 in PDB entry 6z8k, assembly 1, top view.
11012345678910
 
510AGUAGUGUGC
Chains
Chain A (auth C)
Chain D (auth T)
Interaction interfaces
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RNA chain X
Name: La Crosse virus 5' vRNA (9-16)
Representative chains: X
Source organism: Orthobunyavirus lacrosseense [3052409]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.51 KDa
La Crosse virus 5' vRNA (9-16) in PDB entry 6z8k, assembly 1, front view.
La Crosse virus 5' vRNA (9-16) in PDB entry 6z8k, assembly 1, side view.
La Crosse virus 5' vRNA (9-16) in PDB entry 6z8k, assembly 1, top view.
181.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0
 
2468GCUACCAA
Chains
Chain B (auth X)
Interaction interfaces
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RNA chains H, P
Name: La Crosse virus 3' vRNA (1-16)
Representative chains: H, P
Source organism: Orthobunyavirus lacrosseense [3052409]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 5.06 KDa
La Crosse virus 3' vRNA (1-16) in PDB entry 6z8k, assembly 1, front view.
La Crosse virus 3' vRNA (1-16) in PDB entry 6z8k, assembly 1, side view.
La Crosse virus 3' vRNA (1-16) in PDB entry 6z8k, assembly 1, top view.
116246810121416
 
51015UUGGUAGUACACUACU
Chains
Chain C (auth H)
Chain E (auth P)
Interaction interfaces
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