› 6zbe

Electron Microscopy
3.3Å resolution

Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 1

Released:
DOI: 10.2210/pdb6zbe/pdb
PDB entry 6zbe coloured by chain, front view.
PDB entry 6zbe coloured by chain, side view.
PDB entry 6zbe coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Structure of the merozoite surface protein 1 from Plasmodium falciparum.
Dijkman PM, Marzluf T, Zhang Y, Chang SS, Helm D, Lanzer M, Bujard H, Kudryashev M
Sci Adv 7 (2021)
PMID: 34078606
Related structures: EMD-11152

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111370 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Merozoite surface protein 1 Chain: A
Molecule details ›
Chain: A
Length: 717 amino acids
Theoretical weight: 81.77 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q25922 (Residues: 20-736; Coverage: 42%)
Gene name: gp190/ MSA1/ MSP1/ PMMSA
p30 subunit Chain: B
Molecule details ›
Chain: B
Length: 174 amino acids
Theoretical weight: 20.22 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I0U8 (Residues: 737-910; Coverage: 10%)
Gene names: MSP-1, MSP1, PF3D7_0930300
p38 subunit Chain: C
Molecule details ›
Chain: C
Length: 416 amino acids
Theoretical weight: 46.39 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I0U8 (Residues: 911-1326; Coverage: 25%)
Gene names: MSP-1, MSP1, PF3D7_0930300
Sequence domains: Merozoite surface protein 1 (MSP1) C-terminus
Merozoite surface protein 1 Chain: D
Molecule details ›
Chain: D
Length: 376 amino acids
Theoretical weight: 43.24 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: C4PDY5 (Residues: 1-376; Coverage: 100%)
Gene name: msp1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-11152
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Plasmodium 6-Cysteine Proteins: Functional Diversity, Transmission-Blocking Antibodies and Structural Scaffolds.
Lyons et al. (2022)
2 more