› 6zdu

X-ray diffraction
3.45Å resolution

Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA

Released:
DOI: 10.2210/pdb6zdu/pdb
PDB entry 6zdu coloured by chain, front view.
PDB entry 6zdu coloured by chain, side view.
PDB entry 6zdu coloured by chain, top view.
Source organism: Candida albicans SC5314
Primary publication:
Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.
Zhai LT, Rety S, Chen WF, Song ZY, Auguin D, Sun B, Dou SX, Xi XG
OpenAccess logo Nucleic Acids Res 49 4768-4781 (2021)
PMID: 33856462

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103394 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Telomerase reverse transcriptase Chains: A, B
Molecule details ›
Chains: A, B
Length: 773 amino acids
Theoretical weight: 90.09 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: A0A1D8PEA0 (Residues: 95-867; Coverage: 89%)
Gene names: CAALFM_C108130CA, TERT, orf19.12555
Sequence domains:
Chains: C,D Chains: C, D
Molecule details ›
Chains: C, D
Length: 65 nucleotides
Theoretical weight: 21.03 KDa
Source organism: Candida albicans SC5314
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P21212
Unit cell:
a: 149.884Å b: 245.836Å c: 72.471Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.248 0.301
Expression systems:
  • Escherichia coli 'BL21-Gold(DE3)pLysS AG'
  • Not provided

Quick links

Citations

2 review citations

G-quadruplex DNA: a novel target for drug design.
Teng et al. (2021)
1 more

2 mentions without citation

Telomerase structural biology comes of age.
He et al. (2022)
1 more