› 6zdy

X-ray diffraction
1.45Å resolution

Crystal structure of WT murine S100A9 bound to calcium and zinc

Released:
DOI: 10.2210/pdb6zdy/pdb
PDB entry 6zdy coloured by chain, front view.
PDB entry 6zdy coloured by chain, side view.
PDB entry 6zdy coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Divalent cations influence the dimerization mode of murine S100A9 protein by modulating its disulfide bond pattern.
Signor L, Paris T, Mas C, Picard A, Lutfalla G, Boeri Erba E, Yatime L
J Struct Biol 213 107689 (2021)
PMID: 33359632

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152077 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A9 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13.2 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31725 (Residues: 1-113; Coverage: 100%)
Gene names: Cagb, Mrp14, S100a9
Sequence domains: S-100/ICaBP type calcium binding domain

Ligands and Environments

3 bound ligands:
Ligand CA 2 x CA
Ligand ZN 2 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 72.84Å b: 40.62Å c: 53.09Å
α: 90° β: 125° γ: 90°
R-values:
R R work R free
0.177 0.176 0.2
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing.
Franz et al. (2022)
2 more

6 mentions without citation

Pathogenic role of S100 proteins in psoriasis.
Liang et al. (2023)
5 more