6zez

X-ray diffraction
2.55Å resolution

Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-195563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 33.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q9Z2X8 (Residues: 322-624; Coverage: 49%)
Gene names: Inrf2, Keap1, Kiaa0132
Sequence domains: Kelch motif

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P61
Unit cell:
a: 103.684Å b: 103.684Å c: 55.029Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.21 0.254
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'