› 6zgt

X-ray diffraction
2.23Å resolution

Crystal structure of a MFS transporter with bound 2-naphthoic acid at 2.39 Angstroem resolution

Released:
DOI: 10.2210/pdb6zgt/pdb
PDB entry 6zgt coloured by chain, front view.
PDB entry 6zgt coloured by chain, side view.
PDB entry 6zgt coloured by chain, top view.
Source organism: Syntrophobacter fumaroxidans MPOB
Primary publication:
The making of a potent L-lactate transport inhibitor
Bosshart PD, Kalbermatter D, Bonetti S, Fotiadis D
Commun Chem 4 128- (2021)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106119 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate transporter Chains: A, B
Molecule details ›
Chains: A, B
Length: 420 amino acids
Theoretical weight: 44.8 KDa
Source organism: Syntrophobacter fumaroxidans MPOB
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0LNN5 (Residues: 1-412; Coverage: 100%)
Gene name: Sfum_3364
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

1 bound ligand:
Ligand FIV 2 x FIV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 102.534Å b: 199.623Å c: 61.934Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.24
Expression system: Escherichia coli BL21(DE3)

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