Function and Biology

Respiratory complex I from Thermus thermophilus, NADH dataset, minor state

Source organism: Thermus thermophilus
Biochemical function: quinone binding
Biological process: proton transmembrane transport
Cellular component: plasma membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00361
Domain description: Proton-conducting membrane transporter
Occurring in:
  1. NADH-quinone oxidoreductase subunit 12
  2. NADH-quinone oxidoreductase subunit 13
  3. NADH-quinone oxidoreductase subunit 14
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-quinone oxidoreductase subunit 12. Showing 1 copy in chain L.
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-quinone oxidoreductase subunit 13. Showing 1 copy in chain M.
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-quinone oxidoreductase subunit 14. Showing 1 copy in chain N.

PF00037
Domain description: 4Fe-4S binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 9
The deposited structure of PDB entry 6zjn contains 2 copies of Pfam domain PF00037 (4Fe-4S binding domain) in NADH-quinone oxidoreductase subunit 9. Showing 2 copies in chain G [auth 9].

PF00662
Domain description: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
Occurring in:
  1. NADH-quinone oxidoreductase subunit 12
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00662 (NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus) in NADH-quinone oxidoreductase subunit 12. Showing 1 copy in chain L.

PF00420
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
Occurring in:
  1. NADH-quinone oxidoreductase subunit 11
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00420 (NADH-ubiquinone/plastoquinone oxidoreductase chain 4L) in NADH-quinone oxidoreductase subunit 11. Showing 1 copy in chain K.

PF00499
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
Occurring in:
  1. NADH-quinone oxidoreductase subunit 10
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00499 (NADH-ubiquinone/plastoquinone oxidoreductase chain 6) in NADH-quinone oxidoreductase subunit 10. Showing 1 copy in chain J.

PF00146
Domain description: NADH dehydrogenase
Occurring in:
  1. NADH-quinone oxidoreductase subunit 8
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00146 (NADH dehydrogenase) in NADH-quinone oxidoreductase subunit 8. Showing 1 copy in chain O [auth H].

PF00507
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
Occurring in:
  1. NADH-quinone oxidoreductase subunit 7
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00507 (NADH-ubiquinone/plastoquinone oxidoreductase, chain 3) in NADH-quinone oxidoreductase subunit 7. Showing 1 copy in chain I [auth A].

PF11497
Domain description: NADH-quinone oxidoreductase chain 15
Occurring in:
  1. NADH-quinone oxidoreductase subunit 15
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF11497 (NADH-quinone oxidoreductase chain 15) in NADH-quinone oxidoreductase subunit 15. Showing 1 copy in chain H [auth 7].

PF01058
Domain description: NADH ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 6
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit) in NADH-quinone oxidoreductase subunit 6. Showing 1 copy in chain F [auth 6].

PF00329
Domain description: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 5
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00329 (Respiratory-chain NADH dehydrogenase, 30 Kd subunit) in NADH-quinone oxidoreductase subunit 5. Showing 1 copy in chain E [auth 5].

PF00346
Domain description: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 4
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00346 (Respiratory-chain NADH dehydrogenase, 49 Kd subunit) in NADH-quinone oxidoreductase subunit 4. Showing 1 copy in chain D [auth 4].

PF01568
Domain description: Molydopterin dinucleotide binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF01568 (Molydopterin dinucleotide binding domain) in NADH-quinone oxidoreductase subunit 3. Showing 1 copy in chain C [auth 3].

PF00384
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00384 (Molybdopterin oxidoreductase) in NADH-quinone oxidoreductase subunit 3. Showing 1 copy in chain C [auth 3].

PF04879
Domain description: Molybdopterin oxidoreductase Fe4S4 domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF04879 (Molybdopterin oxidoreductase Fe4S4 domain) in NADH-quinone oxidoreductase subunit 3. Showing 1 copy in chain C [auth 3].

PF22117
Domain description: NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3

PF10588
Domain description: NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) in NADH-quinone oxidoreductase subunit 3. Showing 1 copy in chain C [auth 3].

PF00111
Domain description: 2Fe-2S iron-sulfur cluster binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF00111 (2Fe-2S iron-sulfur cluster binding domain) in NADH-quinone oxidoreductase subunit 3. Showing 1 copy in chain C [auth 3].

PF01257
Domain description: Thioredoxin-like [2Fe-2S] ferredoxin
Occurring in:
  1. NADH-quinone oxidoreductase subunit 2
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF01257 (Thioredoxin-like [2Fe-2S] ferredoxin) in NADH-quinone oxidoreductase subunit 2. Showing 1 copy in chain B [auth 2].

PF10589
Domain description: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region) in NADH-quinone oxidoreductase subunit 1. Showing 1 copy in chain A [auth 1].

PF10531
Domain description: SLBB domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF10531 (SLBB domain) in NADH-quinone oxidoreductase subunit 1. Showing 1 copy in chain A [auth 1].

PF22461
Domain description: SLBB domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1

PF01512
Domain description: Respiratory-chain NADH dehydrogenase 51 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
The deposited structure of PDB entry 6zjn contains 1 copy of Pfam domain PF01512 (Respiratory-chain NADH dehydrogenase 51 Kd subunit) in NADH-quinone oxidoreductase subunit 1. Showing 1 copy in chain A [auth 1].

InterPro InterPro annotations
IPR003918
Domain description: NADH:ubiquinone oxidoreductase
Occurring in:
  1. NADH-quinone oxidoreductase subunit 13
IPR001750
Domain description: NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 12
  2. NADH-quinone oxidoreductase subunit 13
  3. NADH-quinone oxidoreductase subunit 14
IPR001694
Domain description: NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H
Occurring in:
  1. NADH-quinone oxidoreductase subunit 8
IPR017896
Domain description: 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 9
IPR010226
Domain description: NADH-quinone oxidoreductase, chain I
Occurring in:
  1. NADH-quinone oxidoreductase subunit 9
IPR006138
Domain description: NADH-ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 6
IPR022885
Domain description: NAD(P)H-quinone oxidoreductase subunit D/H
Occurring in:
  1. NADH-quinone oxidoreductase subunit 4
IPR006963
Domain description: Molybdopterin oxidoreductase, 4Fe-4S domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR019574
Domain description: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR000283
Domain description: NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR002023
Domain description: NADH-quinone oxidoreductase subunit E-like
Occurring in:
  1. NADH-quinone oxidoreductase subunit 2
IPR001133
Domain description: NADH-ubiquinone oxidoreductase chain 4L/K
Occurring in:
  1. NADH-quinone oxidoreductase subunit 11
IPR018086
Domain description: NADH:ubiquinone oxidoreductase, subunit 1, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit 8
IPR000440
Domain description: NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
Occurring in:
  1. NADH-quinone oxidoreductase subunit 7
IPR037232
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 5
IPR029014
Domain description: [NiFe]-hydrogenase, large subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 4
IPR001041
Domain description: 2Fe-2S ferredoxin-type iron-sulfur binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR019575
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
IPR037207
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
IPR001949
Domain description: NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
IPR037225
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
IPR010096
Domain description: NAD(P)H-quinone oxidoreductase, subunit N/subunit 2
Occurring in:
  1. NADH-quinone oxidoreductase subunit 14
IPR010227
Domain description: NADH-quinone oxidoreductase, chain M/4
Occurring in:
  1. NADH-quinone oxidoreductase subunit 13
IPR001516
Domain description: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal
Occurring in:
  1. NADH-quinone oxidoreductase subunit 12
IPR018393
Domain description: NADH-plastoquinone oxidoreductase, chain 5 subgroup
Occurring in:
  1. NADH-quinone oxidoreductase subunit 12
IPR003945
Domain description: NADH-quinone oxidoreductase, chain 5-like
Occurring in:
  1. NADH-quinone oxidoreductase subunit 12
IPR039428
Domain description: NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like
Occurring in:
  1. NADH-quinone oxidoreductase subunit 11
IPR001457
Domain description: NADH:ubiquinone/plastoquinone oxidoreductase, chain 6
Occurring in:
  1. NADH-quinone oxidoreductase subunit 10
IPR042106
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ
Occurring in:
  1. NADH-quinone oxidoreductase subunit 10
IPR023043
Domain description: NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid
Occurring in:
  1. NADH-quinone oxidoreductase subunit 7
IPR038430
Domain description: NADH:ubiquinone oxidoreductase, subunit 3 superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 7
IPR017900
Domain description: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit 9
IPR021093
Domain description: NADH-quinone oxidoreductase, subunit15
Occurring in:
  1. NADH-quinone oxidoreductase subunit 15
IPR036524
Domain description: Frataxin/CyaY superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 15
IPR038458
Domain description: NADH-quinone oxidoreductase, subunit 15 superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 15
IPR006137
Domain description: NADH:ubiquinone oxidoreductase-like, 20kDa subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 6
IPR020396
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit 5
IPR001268
Domain description: NADH:ubiquinone oxidoreductase, 30kDa subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 5
IPR010218
Domain description: NADH dehydrogenase, subunit C
Occurring in:
  1. NADH-quinone oxidoreductase subunit 5
IPR001135
Domain description: NADH-quinone oxidoreductase, subunit D
Occurring in:
  1. NADH-quinone oxidoreductase subunit 4
IPR014029
Domain description: NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site
Occurring in:
  1. NADH-quinone oxidoreductase subunit 4
IPR006657
Domain description: Molybdopterin dinucleotide-binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR009010
Domain description: Aspartate decarboxylase-like domain superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR001387
Domain description: Cro/C1-type helix-turn-helix domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR006656
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR010228
Domain description: NADH:ubiquinone oxidoreductase, subunit G
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR036010
Domain description: 2Fe-2S ferredoxin-like superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 3
IPR042128
Domain description: NuoE domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 2
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. NADH-quinone oxidoreductase subunit 2
IPR041921
Domain description: NADH-quinone oxidoreductase subunit E, N-terminal
Occurring in:
  1. NADH-quinone oxidoreductase subunit 2
IPR019554
Domain description: Soluble ligand binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
IPR011538
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1
IPR011537
Domain description: NADH ubiquinone oxidoreductase, F subunit
Occurring in:
  1. NADH-quinone oxidoreductase subunit 1