Function and Biology Details
Reaction catalysed:
L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
Tyrosine 3-monooxygenase (preferred)
PDBe Complex ID:
PDB-CPX-139373 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine 3-monooxygenase
Molecule details ›
Chains: A, C, E, G
Length: 335 amino acids
Theoretical weight: 38.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Biopterin-dependent aromatic amino acid hydroxylase
Length: 335 amino acids
Theoretical weight: 38.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P07101 (Residues: 194-528; Coverage: 63%)
Sequence domains: Biopterin-dependent aromatic amino acid hydroxylase
Tyrosine 3-monooxygenase
Molecule details ›
Chains: B, D, F, H
Length: 18 amino acids
Theoretical weight: 1.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Tyrosine hydroxylase N terminal
Length: 18 amino acids
Theoretical weight: 1.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P07101 (Residues: 71-88; Coverage: 3%)
Sequence domains: Tyrosine hydroxylase N terminal
