EC 3.4.19.12: Ubiquitinyl hydrolase 1
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
- Ubiquitin C-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin thiolesterase
- Yeast ubiquitin hydrolase
EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase
Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Systematic name:
DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase
Alternative Name(s):
- AP endonuclease class I
- AP lyase
- AP site-DNA 5'-phosphomonoester-lyase
- Deoxyribonuclease (apurinic or apyrimidinic)
- E. coli endonuclease III
- E.coli endonuclease III
- Endodeoxyribonuclease (apurinic or apyrimidinic)
- Micrococcus luteus UV endonuclease
- Phage-T(4) UV endonuclease
- Phage-T4 UV endonuclease
- X-ray endonuclease III
EC 3.6.5.3: Protein-synthesizing GTPase
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (mRNA-translation-assisting)
Alternative Name(s):
- Elongation factor (EF)
- Initiation factor (IF)
- Peptide-release factor (RF)
- Peptide-release or termination factor
EC 3.6.4.13: RNA helicase
Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
- CSFV NS3 helicase
- DBP2
- DDX17
- DDX25
- DDX3
- DDX3X
- DDX3Y
- DDX4
- DDX5
- DEAD-box RNA helicase
- DEAD-box protein DED1
- DEAH-box RNA helicase
- DEAH-box protein 2
- DED1
- DbpA
- Dex(H/D) RNA helicase
- EIF4A helicase
- EhDEAD1
- EhDEAD1 RNA helicase
- GRTH/DDX25
- KOKV helicase
- Mtr4p
- NPH-II
- Nonstructural protein 3 helicase
- RHA
- RNA helicase A
- RNA helicase DDX3
- RNA helicase Hera
- RNA-dependent ATPase
- TGBp1 NTPase/helicase domain
- VRH1
EC 3.6.4.12: DNA helicase
Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
- 3' to 5' DNA helicase
- 3'-5' DNA helicase
- 3'-5' PfDH
- 5' to 3' DNA helicase
- AvDH1
- BACH1 helicase
- BLM protein
- BRCA1-associated C-terminal helicase
- BcMCM
- CeWRN-1
- DNA helicase 120
- DNA helicase A
- DNA helicase E
- DNA helicase II
- DNA helicase III
- DNA helicase RECQL5'
- DNA helicase VI
- Dbp9p
- DmRECQ5
- DnaB
- DnaB helicase E1
- HHcsA
- HPif1
- Hel E
- Helicase DnaB
- Helicase HDH IV
- Helicase domain of bacteriophage T7 gene 4 protein helicase
- Hmi1p
- MCM helicase
- MCM protein
- MER3 helicase
- MER3 protein
- MPH1
- PDH120
- PIF1
- PcrA
- PcrA helicase
- PfDH A
- Pfh1p
- UvrD
EC 3.4.22.69: SARS coronavirus main proteinase
Reaction catalysed:
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
Systematic name:
-
Alternative Name(s):
- 3C-like protease
- 3cLpro
- Coronavirus 3C-like protease
- Mpro
- SARS 3C-like protease
- SARS coronavirus 3CL protease
- SARS coronavirus main peptidase
- SARS coronavirus main protease
- SARS-CoV 3CLpro enzyme
- SARS-CoV Mpro
- SARS-CoV main protease
- Severe acute respiratory syndrome coronavirus main protease
EC 2.7.7.50: mRNA guanylyltransferase
Reaction catalysed:
GTP + a 5'-diphospho-[mRNA] = diphosphate + a 5'-(5'-triphosphoguanosine)-[mRNA]
Systematic name:
GTP:mRNA guanylyltransferase
Alternative Name(s):
- GTP--RNA guanylyltransferase
- Messenger RNA guanylyltransferase
- Protein lambda-2
- mRNA capping enzyme
EC 2.7.7.48: RNA-directed RNA polymerase
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
- 3D polymerase
- PB1 proteins
- PB2 proteins
- Phage f2 replicase
- Polymerase L
- Q-beta replicase
- RDRP
- RNA nucleotidyltransferase (RNA-directed)
- RNA replicase
- RNA synthetase
- RNA transcriptase
- RNA-dependent RNA polymerase
- RNA-dependent RNA replicase
- RNA-dependent ribonucleate nucleotidyltransferase
- Ribonucleic acid replicase
- Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
- Ribonucleic acid-dependent ribonucleic acid polymerase
- Ribonucleic replicase
- Ribonucleic synthetase
- Transcriptase
EC 2.1.1.57: Methyltransferase cap1
Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Alternative Name(s):
- Cap1-MTase
- MTR1
- Messenger RNA (nucleoside-2'-)-methyltransferase
- Messenger ribonucleate nucleoside 2'-methyltransferase
- S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
- mRNA (nucleoside-2'-O)-methyltransferase
EC 2.1.1.56: mRNA (guanine-N(7))-methyltransferase
Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:mRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
- Guanine-7-methyltransferase
- Messenger RNA guanine 7-methyltransferase
- Messenger ribonucleate guanine 7-methyltransferase
- S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase
GO terms
Sequence families
Protein families (Pfam)
PF05091
Domain description:
Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
Occurring in:
Occurring in:
PF21357
Domain description:
Eukaryotic translation initiation factor 3 subunit E, C-terminal
Occurring in:
Occurring in:
PF05470
Domain description:
Eukaryotic translation initiation factor 3 subunit 8 N-terminus
Occurring in:
Occurring in:
RNA families (Rfam)
InterPro annotations
IPR000717
Domain description:
Proteasome component (PCI) domain
Occurring in:
Occurring in:
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit E
- Eukaryotic translation initiation factor 3 subunit K
- Eukaryotic translation initiation factor 3 subunit L
- Eukaryotic translation initiation factor 3 subunit M
IPR023029
Domain description:
Small ribosomal subunit protein uS15, archaea/eukaryotes
Occurring in:
Occurring in:
IPR005680
Domain description:
Small ribosomal subunit protein uS12, eukaryotic/archaeal
Occurring in:
Occurring in:
IPR014721
Domain description:
Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Occurring in:
Occurring in:
IPR005707
Domain description:
Small ribosomal subunit protein uS2, eukaryotic/archaeal
Occurring in:
Occurring in:
IPR024055
Domain description:
Translation initiation factor 2, alpha subunit, C-terminal
Occurring in:
Occurring in:
IPR024054
Domain description:
Translation initiation factor 2, alpha subunit, middle domain superfamily
Occurring in:
Occurring in:
IPR012678
Domain description:
Ribosomal protein uL23/eL15/eS24 core domain superfamily
Occurring in:
Occurring in:
IPR042563
Domain description:
Small ribosomal subunit protein eS8 subdomain, eukaryotes
Occurring in:
Occurring in:
IPR038237
Domain description:
Small ribosomal subunit protein eS4, central domain superfamily
Occurring in:
Occurring in:
IPR018199
Domain description:
Small ribosomal subunit protein eS4, N-terminal, conserved site
Occurring in:
Occurring in:
IPR005713
Domain description:
Small ribosomal subunit protein uS19, eukaryotic/archaeal
Occurring in:
Occurring in:
IPR028333
Domain description:
Small ribosomal subunit protein uS17, archaeal/eukaryotic
Occurring in:
Occurring in:
IPR039744
Domain description:
Small ribosomal subunit protein uS14, eukaryotes/archaea
Occurring in:
Occurring in:
IPR005729
Domain description:
Small ribosomal subunit protein uS10, eukaryotic/archaeal
Occurring in:
Occurring in:
IPR018192
Domain description:
Small ribosomal subunit protein uS5, N-terminal, conserved site
Occurring in:
Occurring in:
IPR005711
Domain description:
Small ribosomal subunit protein uS5, eukaryotic/archaeal
Occurring in:
Occurring in:
IPR005710
Domain description:
Small ribosomal subunit protein uS4, eukaryotic/archaeal
Occurring in:
Occurring in:
IPR005703
Domain description:
Small ribosomal subunit protein uS3, eukaryotic/archaeal
Occurring in:
Occurring in:
IPR023591
Domain description:
Small ribosomal subunit protein uS2, flavodoxin-like domain superfamily
Occurring in:
Occurring in:
IPR009001
Domain description:
Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Occurring in:
Occurring in:
IPR038582
Domain description:
Small ribosomal subunit protein eS31 eukaryotic-type superfamily
Occurring in:
Occurring in:
IPR023407
Domain description:
Small ribosomal subunit protein eS27, zinc-binding domain superfamily
Occurring in:
Occurring in:
IPR045237
Domain description:
Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7
Occurring in:
Occurring in:
IPR016020
Domain description:
Translation initiation factor 3, subunit 12, N-terminal, eukaryotic
Occurring in:
Occurring in:
IPR018104
Domain description:
Translation initiation factor 1A (eIF-1A), conserved site
Occurring in:
Occurring in:
IPR019010
Domain description:
Eukaryotic translation initiation factor 3 subunit E, N-terminal
Occurring in:
Occurring in:
IPR008905
Domain description:
Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
Occurring in:
Occurring in:
IPR013979
Domain description:
Translation initiation factor, beta propellor-like domain
Occurring in:
Occurring in: