Function and Biology Details
Reaction catalysed:
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Bacterial exotoxin B
- Anthrax toxin, lethal/endema factor
- PA14 domain
- Protective antigen, domain 4
- Clostridial binary toxin B/anthrax toxin PA, domain 3
- Protective antigen, heptamerisation domain
- Protective antigen, heptamerisation domain superfamily
- Protective antigen, Ca-binding domain
5 more domains
Structure analysis Details
Assembly composition:
hetero decamer (preferred)
Assembly name:
Lethal factor and Protective antigen (preferred)
PDBe Complex ID:
PDB-CPX-146584 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):