› 7a57

X-ray diffraction
3.16Å resolution

La Crosse Virus Envelope Glycoprotein Gc W1066H Mutant Fusion Domains in Postfusion Conformation

Released:
DOI: 10.2210/pdb7a57/pdb
PDB entry 7a57 coloured by chain, front view.
PDB entry 7a57 coloured by chain, side view.
PDB entry 7a57 coloured by chain, top view.
Source organism: La Crosse virus L78
Primary publication:
Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.
Hellert J, Aebischer A, Haouz A, Guardado-Calvo P, Reiche S, Beer M, Rey FA
Cell Rep 42 112142 (2023)
PMID: 36827185

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-569056 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycoprotein C Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 458 amino acids
Theoretical weight: 50.94 KDa
Source organism: La Crosse virus L78
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q8JPR1 (Residues: 918-1364; Coverage: 31%)
Gene name: GP
Sequence domains: Bunyavirus glycoprotein G1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P6122
Unit cell:
a: 170.873Å b: 170.873Å c: 379.22Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.226
Expression system: Drosophila melanogaster

Quick links

Citations

1 review citation

Innate immune response against vector-borne bunyavirus infection and viral countermeasures.
Li M. (2024)
2 other articles

3 mentions without citation

Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K+ during entry.
Hover et al. (2023)
2 more