› 7amk

X-ray diffraction
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (7 distinct):
Proto-oncogene tyrosine-protein kinase receptor Ret Chains: A, B
Molecule details ›
Chains: A, B
Length: 480 amino acids
Theoretical weight: 54.61 KDa
Source organism: Danio rerio
Expression system: unidentified baculovirus
UniProt:
  • Canonical: A8E7C6 (Residues: 23-502; Coverage: 44%)
Gene names: c-ret, cret, etID315074.13, ret, ret1, wu:fd13h01
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
6 bound ligands:
Ligand CA 6 x CA
Ligand NAG 3 x NAG
Ligand GOL 4 x GOL
Ligand PGE 5 x PGE
Ligand PEG 10 x PEG
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 51.167Å b: 70.499Å c: 105.438Å
α: 105.408° β: 100.934° γ: 100.253°
R-values:
R R work R free
0.227 0.225 0.269
Expression system: unidentified baculovirus

Quick links

Citations

1 review citation

RET receptor signaling: Function in development, metabolic disease, and cancer.
Takahashi M. (2022)
3 other articles

2 mentions without citation

Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.
Cai et al. (2022)
1 more