› 7aw6

X-ray diffraction
1.95Å resolution

The extracellular region of CD33 with bound sialoside analogue P22

Released:
DOI: 10.2210/pdb7aw6/pdb
PDB entry 7aw6 coloured by chain, front view.
PDB entry 7aw6 coloured by chain, side view.
PDB entry 7aw6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bradshaw WJ, Katis VL, Thompson AP, Arrowsmith CH, Edwards AM, von Delft F, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148857 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid cell surface antigen CD33 Chains: A, B
Molecule details ›
Chains: A, B
Length: 252 amino acids
Theoretical weight: 27.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20138 (Residues: 21-232; Coverage: 61%)
  • Best match: P20138-3 (Residues: 12-105)
Gene names: CD33, SIGLEC3
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand NAG 9 x NAG
Ligand FVP 2 x FVP
Ligand PO4 1 x PO4
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 59.641Å b: 103.23Å c: 84.495Å
α: 90° β: 110.42° γ: 90°
R-values:
R R work R free
0.196 0.194 0.246
Expression system: Homo sapiens

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