› 7b75

Electron Microscopy
3.2Å resolution

Cryo-EM Structure of Human Thyroglobulin

Released:
DOI: 10.2210/pdb7b75/pdb
PDB entry 7b75 coloured by chain, front view.
PDB entry 7b75 coloured by chain, side view.
PDB entry 7b75 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of native human thyroglobulin.
Adaixo R, Steiner EM, Righetto RD, Schmidt A, Stahlberg H, Taylor NMI
OpenAccess logo Nat Commun 13 61 (2022)
PMID: 35013249
Related structures: EMD-12073

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-524874 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Thyroglobulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 2768 amino acids
Theoretical weight: 305.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01266 (Residues: 1-2768; Coverage: 100%)
Gene name: TG
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 16 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-12073

Quick links

Citations

2 review citations

A glance at post-translational modifications of human thyroglobulin: potential impact on function and pathogenesis.
Tosatto et al. (2022)
1 more