› 7bso

X-ray diffraction
2.08Å resolution

Crystal structure of the human NLRP9 pyrin domain

Released:
DOI: 10.2210/pdb7bso/pdb
PDB entry 7bso coloured by chain, front view.
PDB entry 7bso coloured by chain, side view.
PDB entry 7bso coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human NLRP9 pyrin domain reveals a bent N-terminal loop that may regulate inflammasome assembly.
Ha HJ, Park HH
FEBS Lett 594 2396-2405 (2020)
PMID: 32542766

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-566064 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 9 Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 12.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7RTR0 (Residues: 1-96; Coverage: 10%)
Gene names: NALP9, NLRP9, NOD6, PAN12
Sequence domains: PAAD/DAPIN/Pyrin domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: C2
Unit cell:
a: 51.97Å b: 33.685Å c: 49.667Å
α: 90° β: 102.397° γ: 90°
R-values:
R R work R free
0.217 0.213 0.282
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

ATP-Binding and Hydrolysis in Inflammasome Activation.
Sandall et al. (2020)
5 more