› 7c02

X-ray diffraction
2.91Å resolution

Crystal structure of dimeric MERS-CoV receptor binding domain

Released:
DOI: 10.2210/pdb7c02/pdb
PDB entry 7c02 coloured by chain, front view.
PDB entry 7c02 coloured by chain, side view.
PDB entry 7c02 coloured by chain, top view.
Source organism: Middle East respiratory syndrome-related coronavirus
Primary publication:
A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS.
Dai L, Zheng T, Xu K, Han Y, Xu L, Huang E, An Y, Cheng Y, Li S, Liu M, Yang M, Li Y, Cheng H, Yuan Y, Zhang W, Ke C, Wong G, Qi J, Qin C, Yan J, Gao GF
OpenAccess logo Cell 182 722-733.e11 (2020)
PMID: 32645327

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spike protein S1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 27.11 KDa
Source organism: Middle East respiratory syndrome-related coronavirus
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: K9N5Q8 (Residues: 367-606; Coverage: 18%)
Gene names: 3, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 46.463Å b: 108.788Å c: 125.448Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.262
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

72 review citations

Viral targets for vaccines against COVID-19.
Dai et al. (2021)
71 more

2 mentions without citation

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS.
Dai et al. (2020)
1 more