› 7c3m

X-ray diffraction
3.6Å resolution

Structure of FERM protein

Released:
DOI: 10.2210/pdb7c3m/pdb
PDB entry 7c3m coloured by chain, front view.
PDB entry 7c3m coloured by chain, side view.
PDB entry 7c3m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state.
Bu W, Levitskaya Z, Loh ZY, Jin S, Basu S, Ero R, Yan X, Wang M, Ngan SFC, Sze SK, Tan SM, Gao YG
OpenAccess logo PLoS Biol 18 e3000755 (2020)
PMID: 32644996

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-567287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fermitin family homolog 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 675 amino acids
Theoretical weight: 76.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86UX7 (Residues: 1-667; Coverage: 100%)
Gene names: FERMT3, KIND3, MIG2B, URP2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2221
Unit cell:
a: 115.76Å b: 204.62Å c: 269.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.306 0.305 0.317
Expression system: Escherichia coli

Quick links

Citations

9 review citations

β2 Integrin Signaling Cascade in Neutrophils: More Than a Single Function.
Bouti et al. (2020)
8 more

5 mentions without citation

Case Report: A Case of Leukocyte Adhesion Deficiency, Type III Presenting With Impaired Platelet Function, Lymphocytosis and Granulocytosis.
Yahya et al. (2021)
4 more